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1.
目的 探讨血液肿瘤患者接受化疗后发生肛周感染的危险因素。方法 采用回顾性病例对照研究的方法,对四川省某三级甲等医院血液内科2020年12月—2021年5月收治的进行化疗的348例血液肿瘤住院患者相关资料(人口学特征、疾病特征、医疗及护理病例记录、实验室检查结果)予以回顾性分析,根据出院诊断发生肛周感染的病例作为病例组,其余病例作为对照组,统计血液肿瘤患者接受化疗后肛周感染的发生率,采用单因素分析和二元Logistic回归分析肛周感染的危险因素。结果 348例血液肿瘤化疗患者,发生肛周感染35例,感染率为10.1%;Logistic回归分析显示,年龄<60岁(OR=8.776,P=0.039)、痔疮史(OR=7.733,P<0.001)、肛周感染史(OR=14.981,P<0.001)、腹泻(OR=3.893,P=0.019)及白细胞计数<1×109/L(OR=6.851,P=0.002)是血液肿瘤患者接受化疗后发生肛周感染的独立危险因素。结论 血液肿瘤患者接受化疗后肛周感染的发生率较高,年龄<60岁、痔疮史、肛周感染史、腹泻、白细胞计数<1×109/L导致血液肿瘤化疗患者肛周感染率增加,在护理化疗期的血液肿瘤患者过程中,应该结合肛周感染的危险因素,采取针对性干预措施,降低肛周感染发生率。 相似文献
2.
In this paper, a high-order moment-based multi-resolution Hermite
weighted essentially non-oscillatory (HWENO) scheme is designed for hyperbolic conservation laws. The main idea of this scheme is derived from our previous work [J.
Comput. Phys., 446 (2021) 110653], in which the integral averages of the function and
its first order derivative are used to reconstruct both the function and its first order
derivative values at the boundaries. However, in this paper, only the function values at
the Gauss-Lobatto points in the one or two dimensional case need to be reconstructed
by using the information of the zeroth and first order moments. In addition, an extra
modification procedure is used to modify those first order moments in the troubled-cells, which leads to an improvement of stability and an enhancement of resolution
near discontinuities. To obtain the same order of accuracy, the size of the stencil required by this moment-based multi-resolution HWENO scheme is still the same as the
general HWENO scheme and is more compact than the general WENO scheme. Moreover, the linear weights are not unique and are independent of the node position, and
the CFL number can still be 0.6 whether for the one or two dimensional case, which has
to be 0.2 in the two dimensional case for other HWENO schemes. Extensive numerical
examples are given to demonstrate the stability and resolution of such moment-based
multi-resolution HWENO scheme. 相似文献
3.
Raymond E. Chen Emma Knapp Bowen Qiu Anthony Miniaci Hani A. Awad Ilya Voloshin 《Seminars in Arthroplasty》2022,32(1):145-153
BackgroundThe purpose of this study was to compare initial fixation strength between various stemless and stemmed humeral components and to correlate implant fixation strength with bone mineral density (BMD).MethodsFive humeral stem designs were investigated: Stemless-A (four hollow fins), Stemless-B (central body, three solid fins), Stemless-C (central screw, peripheral rim-fit), Short stem (50 mm), and Standard stem (130 mm). Fifty cadaveric human humerii were obtained and divided into five groups. BMD within the humeral head was determined for all samples. The mean BMD was similar between groups. The 25 samples with the lowest and highest BMDs were categorized as “Low” and “High,” respectively, with a BMD threshold of 0.35 g/cm2, creating BMD subgroups. After implantation, each sample underwent a standardized biomechanical testing protocol, with axial loading followed by torsional loading. Sensors attached to the specimen recorded micromotion throughout testing. Axial loading consisted of cyclic loading for 100 cycles at 3 peak forces (220, 520, and 820 N). Torsional loading consisted of 100 cycles of internal/external rotation at 0.1 Hz at 6 peak torques, or until failure (±2.5, 5, 7.5, 10, 12.5, and 15 Nm). Failure was defined as the torque at which any bone fracture, implant detachment from anchor/stem, or an excess of 50° internal/external rotation occurred. Groups and BMD subgroups were compared.ResultsAt maximal axial loading, Stemless-B demonstrated greater micromotion (540 μm) than Stemless-C (192 μm) (P = .003). Stemless-B and Stemless-A (387 μm) also had greater micromotion than Short stem (118 μm, P < .001, P = .03) and Standard stem (85 μm, P < .001, P = .01). When comparing low-BMD samples at maximal axial loading, these differences were accentuated, but comparison of high-BMD samples showed no significant differences between groups. Torsional testing demonstrated that Standard stem failed at greater torque (7.2 Nm) than Stemless-B (2.3 Nm, P < .001), Stemless-A (1.9 Nm, P < .001), and Stemless-C (3.9 Nm, P = .01). When comparing torsional testing results of low-BMD samples, both Standard stem and Short stem failed at greater torque than Stemless-B (P = .02, P = .003) and Stemless-A (P = .03, P = .004) but failed at a similar torque to Stemless-C. Torsional testing of high-BMD samples showed that Standard stem failed at a greater torque than all stemless designs.ConclusionStemless humeral implants should be used with caution in low-BMD settings (<0.35 g/cm2). A central screw and peripheral rim-fit stemless anchor design demonstrated greater fixation strength at low BMD when compared with other designs, while all stemless designs performed similarly at high BMD.Level of evidenceBasic Science Study; Cadaveric Study 相似文献
4.
目的 调查矮小症患儿生活质量现状,并分析其影响因素,以期为改善该类患儿身心健康、促进其健康成长提供参考依据。方法 选取2019年1月—2020年7月湖南省4所三级甲等医院儿科门诊的231例矮小症患儿为研究对象,采用一般资料调查表、儿童生活质量测定量表和儿童自我意识量表对其进行调查。结果 矮小症患儿生活质量总分为(75.57±13.46)分。多元线性回归分析显示,主要照顾者受教育程度、与标准身高差值、自我意识水平为矮小症患儿自我意识水平的独立影响因素(△R2=0.497,F=23.452,P<0.001)。结论 矮小症患儿生活质量欠佳,护理人员以及卫生保健人员应引起重视。不同特征的患儿生活质量存在较大的差异,主要照顾者教育程度低、与标准身高差值大以及自我意识较差的儿童生活质量更差。 相似文献
5.
6.
A Well-Balanced Positivity-Preserving Quasi-Lagrange Moving Mesh DG Method for the Shallow Water Equations 下载免费PDF全文
A high-order, well-balanced, positivity-preserving quasi-Lagrange moving
mesh DG method is presented for the shallow water equations with non-flat bottom
topography. The well-balance property is crucial to the ability of a scheme to simulate perturbation waves over the lake-at-rest steady state such as waves on a lake or
tsunami waves in the deep ocean. The method combines a quasi-Lagrange moving
mesh DG method, a hydrostatic reconstruction technique, and a change of unknown
variables. The strategies in the use of slope limiting, positivity-preservation limiting,
and change of variables to ensure the well-balance and positivity-preserving properties are discussed. Compared to rezoning-type methods, the current method treats
mesh movement continuously in time and has the advantages that it does not need to
interpolate flow variables from the old mesh to the new one and places no constraint
for the choice of a update scheme for the bottom topography on the new mesh. A selection of one- and two-dimensional examples are presented to demonstrate the well-balance property, positivity preservation, and high-order accuracy of the method and
its ability to adapt the mesh according to features in the flow and bottom topography. 相似文献
7.
Metabolic Brain Disease - Bupleurum chinense DC. (Chaihu) is a traditional Chinese medicine (TCM) used in the treatment of anxiety. But the anxiolytic mechanisms of bupleurum are still unclear.... 相似文献
8.
Qi Zhang Ye Zhou Lijie Song Weijia Fang Meng Qiu Yanhong Gu Yang Yang Jingdong Zhang Jing Liu Jian Li Ming Lu Tianxiao Gong Xin Wang Yan Li Jun Yang Yingjiang Ye Lin Shen 《International journal of cancer. Journal international du cancer》2023,153(11):1885-1893
Formal multidisciplinary team (MDT) discussions in clinical practice require time and space but have unclear survival benefits for advanced gastrointestinal cancer patients. Our study aimed to investigate the long-term survival of patients with advanced gastrointestinal cancer after MDT decision. From June 2017 to June 2019, continuous MDT discussions on advanced gastrointestinal cancer were conducted in 13 medical centers in China. MDT decisions and actual treatment received by patients were prospectively recorded. The primary endpoint was the difference in overall survival (OS) between patients in the MDT decision implementation and nonimplementation groups. The secondary endpoints included the implementation rate of MDT decisions and subgroup survival analysis. A total of 461 MDT decisions of 455 patients were included in our study. The implementation rate of MDT decisions was 85.7%. Previous treatment had an impact on MDT decision-making. The OS was 24.0 months and 17.0 months in the implementation and nonimplementation groups, respectively. The implementation of MDT decisions significantly reduced the risk of death in multivariate analyses (hazard ratio = 0.518; 95% confidence interval: 0.304-0.884, P = .016). Subgroup analysis showed a significant difference in survival of patients with colorectal cancer, but not in survival of patients with gastric cancer. The rate of secondary MDT discussion was only 5.6% among patients who the MDT decisions were discontinued due to changes in their condition. MDT discussion can prolong the OS of patients with advanced gastrointestinal cancer, especially those with colorectal cancer. Timely scheduling of the subsequent MDT discussion is necessary when the disease condition changes. 相似文献
9.
目的 研究2-乙酰基毛蕊花糖苷对破骨细胞分化的影响及潜在的分子机制。方法 采用抗酒石酸酸性磷酸酶(TRAP)染色及TRAP酶活力检测法评价0.1、1.0、10.0 μmol·L–1的2-乙酰基毛蕊花糖苷对破骨前体细胞向破骨细胞分化的影响;采用细胞增殖活性检测试剂盒(CCK8)法检测2-乙酰基毛蕊花糖苷对破骨细胞分化的影响;采用F-actin环染色和骨陷窝形成实验检测2-乙酰基毛蕊花糖苷对破骨前体细胞诱导形成的破骨细胞功能的影响;采用蛋白免疫印迹法(WB)检测破骨细胞分化相关特异性蛋白TRAP、整合素β3(ITGβ3)和细胞原癌基因c-Fos的表达水平。结果 与模型组相比,2-乙酰基毛蕊花糖苷显著降低TRAP活性(P<0.05),且对破骨前体细胞活力未见显著影响,提示2-乙酰基毛蕊花糖苷显著抑制破骨细胞形成。F-actin环染色和骨陷窝形成实验也显示2-乙酰基毛蕊花糖苷显著抑制破骨细胞骨吸收功能;WB实验结果表明2-乙酰基毛蕊花糖苷可显著抑制破骨细胞分化特异性蛋白TRAP、ITGβ3和c-Fos等蛋白水平的表达。结论 2-乙酰基毛蕊花糖苷能抑制破骨细胞的形成,作用机制可能与其抑制TRAP、ITGβ3和c-Fos的表达有关。 相似文献
10.
Guo Chengyao Yin Shengjie Qiu Kunliang Zhang Mingzhi 《International ophthalmology》2022,42(7):2029-2038
International Ophthalmology - To evaluate and compare the accuracy of six different formulas (Emmetropia Verifying Optical version 2.0, Kane, SRK/T, Barrett Universal II, Haigis and Olsen) in... 相似文献